The University of North Texas Health Science Center-Texas College of Osteopathic Medicine (UNTHSC-TCOM) is a state-supported osteopathic medical school committed to education, research, patient care, and service.  UNTHSC-TCOM graduates one of the highest percentages of primary care physicians in the nation, and has received recognition both locally and nationally for its efforts to meet the needs of underserved populations.

The curriculum is an innovative model designed to prepare future osteopathic physicians by developing the necessary cognitive and clinical skills to be effective in patient care settings. At the beginning of the first-year students study the fundamentals of health which covers body functions through a systems format. Near the end of the first-year, students will complete a course called Fundamentals of Disease and Treatment which introduces students to common diseases (e.g. infection, inflammation, cancer, etc.). During the second year of the curriculum, students study approximately 1,000 diseases through various patient presentations. These presentations allow students to apply medical knowledge in patient care situations through specific tasks associated with applied learning theory. Course work in medical practice and osteopathic manipulative medicine (OMM) run parallel to the didactic curriculum. They provide the integration of knowledge into clinical practice. Recently, UNTHSC-TCOM added a new four-year professionalism and systems-based practice component to the curriculum which includes topics related to professionalism, patient safety, ethics, population and public health, innovation and entrepreneurship as well as community resources.

The final two years of the curriculum are taught primarily through affiliated hospitals and clinics. Students complete a series of core clinical rotations in family medicine, pediatrics, internal medicine, surgery, psychiatry, obstetrics & gynecology, manipulative medicine and emergency medicine. Students may also complete elective rotations in any number of primary care and specialty settings. 

In the school's 50 year history, UNTHSC-TCOM has graduated over 4,000 osteopathic physicians who have practiced in more than 70 different specialties or subspecialties. In addition to the four-year DO degree program, UNTHSC-TCOM offers dual DO/MPH and DO/PhD programs.  A specialized rural medicine curriculum is also offered for those who wish to have a career in a rural setting.